Preheat your oven to 375°F (190°C). Lightly grease a 9x13 inch baking dish. Freshly grate all cheeses and set aside.
Bring a large pot of water to a rolling boil. Add 1 tablespoon of salt. Cook pasta for 2 minutes less than the package instructions indicate – about 6 minutes for most elbow macaroni. Drain but do not rinse.
While pasta cooks, melt 4 tablespoons butter in a large saucepan over medium heat. Once melted and bubbling subsides, add flour and whisk continuously for 1-2 minutes until the mixture turns light golden and smells slightly nutty.
Gradually add milk to the roux, whisking constantly to prevent lumps. Pour slowly, about 1/2 cup at a time, fully incorporating each addition before adding more. Bring to a gentle simmer and cook for 3-4 minutes until the sauce thickens enough to coat the back of a spoon.
Add mustard powder, cayenne (if using), garlic powder, salt, and pepper.
Remove saucepan from heat. Add grated cheeses in three batches, stirring until completely melted before adding the next batch.
Fold the cooked pasta into the cheese sauce, ensuring every piece is thoroughly coated. Transfer to the prepared baking dish.
In a small bowl, mix panko breadcrumbs with the 2 tablespoons of melted butter. Sprinkle this mixture evenly over the mac and cheese in the baking dish.
Bake uncovered for 25-30 minutes, until the edges are bubbling and the top is golden brown.
Allow to rest for 5-10 minutes before serving. Garnish with fresh parsley just before serving.